2470972-18-8
2470972-18-8
Chemical Structure
Dihydro-5-azacytidine acetate
Synonym(s): DHAC acetate; NSC 264880 acetate
- CAS No.: 2470972-18-8
- Formula:C10H18N4O7
- Molecular Weight:306.27
InChIKey: QJEIZSHIQUKGRJ-MVNLRXSJSA-N
SMILES: NC(NC1)=NC(N1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)=O.CC(O)=O
Biological Activity: Dihydro-5-azacytidine acetate (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine acetate has an antitumor activity[1][2].
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Dihydro-5-azacytidine acetate | Dihydro-5-azacytidine acetate (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine acetate has an antitumor activity. | |||||||||||||||||||||
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References
- [1]. Robert A Kratzke, et al. Response to the methylation inhibitor dihydro-5-azacytidine in mesothelioma is not associated with methylation of p16INK4a: results of cancer and leukemia group B 159904. J Thorac Oncol. 2008 Apr;3(4):417-21. [Content Brief]
- [2]. W C Powell, et al. Biochemical pharmacology of 5,6-dihydro-5-azacytidine (DHAC) and DNA hypomethylation in tumor (L1210)-bearing mice. Cancer Chemother Pharmacol. 1988;21(2):117-21. [Content Brief]
