2477607-64-8
Chemical Structure
DXB-NIR
- CAS No.: 2477607-64-8
- Formula:C28H29BF2N2O5
- Molecular Weight:522.35
InChIKey: KBCOGLWTRUAMBB-WYMLVPIESA-N
SMILES: CCN(C1=CC=C2C(OC(C3=C2OB(F)(O=C3/C=C/C4=CC5=C(O4)C=C(C=C5)N(CC)CC)F)=O)=C1)CC
Biological Activity: DXB-NIR is a push-pull dioxaboron fluorescent probe with solvatochromic properties, featuring high fluorescence brightness, photostability, and a large two-photon absorption cross-section. DXB-NIR exhibits Ex/Em of 550/620–780 nm (with two-photon excitation at 930 nm). DXB-NIR quantifies local polarity via the intensity ratio I (>640)/I (<640) between the far-red channel (<640 nm) and the near-infrared channel (>640 nm), and it can simultaneously label the plasma membrane, endoplasmic reticulum, and lipid droplets in live cells. DXB-NIR monitors the increase in local polarity of various cell compartments under conditions of cholesterol depletion, starvation, and oxidative stress. DXB-NIR can be used for polarity imaging of biological membranes and lipid droplets, as well as studies related to cellular stress[1][2].
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DXB-NIR | DXB-NIR is a push-pull dioxaboron fluorescent probe with solvatochromic properties, featuring high fluorescence brightness, photostability, and a large two-photon absorption cross-section. DXB-NIR exhibits Ex/Em of 550/620–780 nm (with two-photon excitation at 930 nm). DXB-NIR quantifies local polarity via the intensity ratio I (>640)/I (<640) between the far-red channel (<640 nm) and the near-infrared channel (>640 nm), and it can simultaneously label the plasma membrane, endoplasmic reticulum, and lipid droplets in live cells. DXB-NIR monitors the increase in local polarity of various cell compartments under conditions of cholesterol depletion, starvation, and oxidative stress. DXB-NIR can be used for polarity imaging of biological membranes and lipid droplets, as well as studies related to cellular stress. | |||||||||||||||||||||
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References
- [1]. Ashoka AH, et al. Solvatochromic Near-Infrared Probe for Polarity Mapping of Biomembranes and Lipid Droplets in Cells under Stress. The journal of physical chemistry letters. 2019 May 16;10(10):2414-2421.
- [2]. Wang K, et al. Aurone Derivative Revealing the Metabolism of Lipid Droplets and Monitoring Oxidative Stress in Living Cells. Analytical chemistry. 2020 May 05;92(9):6631-6636.
