2479289-15-9
2479289-15-9
Chemical Structure
IHMT-RAF-128
- CAS No.: 2479289-15-9
- Formula:C27H24F3N5O2
- Molecular Weight:507.51
InChIKey: OOJZLOWHTHZMBO-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=CC(C(NC2=CC(N3N=CC(C4=CC(N5CCOCC5)=CN=C4)=C3)=C(C)C=C2)=O)=CC=C1
Biological Activity: IHMT-RAF-128, a highly potent pan-RAF inhibitor. IHMT-RAF-128 shows potent antitumor efficacy in xenograft mouse tumor models without causing any apparent toxicities[1][2].
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IHMT-RAF-128 | IHMT-RAF-128, a highly potent pan-RAF inhibitor. IHMT-RAF-128 shows potent antitumor efficacy in xenograft mouse tumor models without causing any apparent toxicities. | |||||||||||||||||||||
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References
- [1]. Olaoba OT, et al. Driver Mutations in Pancreatic Cancer and Opportunities for Targeted Therapy. Cancers (Basel). 2024 May 9;16(10):1808. [Content Brief]
- [2]. Wang A, et al. Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatment. Eur J Pharmacol. 2023 Aug 5;952:175752. [Content Brief]
