2481321-20-2
Chemical Structure
Anti-Influenza agent 3
- CAS 番号: 2481321-20-2
- Formula:C16H22ClNOS
- Molecular Weight:311.87
IUPAC Name: (E)-(5-chloro-4-methylthiophen-2-yl)((1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl)methanone oxime
InChIKey: CUEYIPMVEFAUPI-CFTOJUNOSA-N
SMILES: O/N=C(C1=CC(C)=C(Cl)S1)\[C@H](C[C@@H]2C[C@H]3C2(C)C)[C@@H]3C
Biological Activity: Anti-Influenza agent 3 (compound 11h) is a potent anti-influenza agent with EC50 values of 3.29, 2.45 µM for A/HK/68 (H3N2, M2-WT), A/WSN/33 (H1N1, M2-S31N) strain, respectively. Anti-Influenza agent 3 shows low cytotoxicity for MDCK epithelial cells. Anti-Influenza agent 3 inhibits the M2 WT and S31N ion channel conductivity[1].
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Anti-Influenza agent 3 | Anti-Influenza agent 3 (compound 11h) is a potent anti-influenza agent with EC50 values of 3.29, 2.45 µM for A/HK/68 (H3N2, M2-WT), A/WSN/33 (H1N1, M2-S31N) strain, respectively. Anti-Influenza agent 3 shows low cytotoxicity for MDCK epithelial cells. Anti-Influenza agent 3 inhibits the M2 WT and S31N ion channel conductivity. | |||||||||||||||||||||
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