2487526-28-1
2487526-28-1
Chemical Structure
GEM144
- CAS No.: 2487526-28-1
- Formula:C28H31NO5
- Molecular Weight:461.55
IUPAC Name: 7-bromoindolizine-2-carboxylic acid
InChIKey: PIJPEZHKJKJZHS-RUDMXATFSA-N
SMILES: ONC(C(C)OC1=C(C=C(C2=CC=C(C=C2)/C=C/C(O)=O)C=C1)C34CC5CC(CC(C5)C4)C3)=O
Biological Activity: GEM144 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts[1].
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GEM144 | GEM144 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts. | |||||||||||||||||||||
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