2492-43-5
Chemical Structure
4-OHE
Synonym(s): (E)-4-Oxo-2-hexenal
- CAS No.: 2492-43-5
- Formula:C6H8O2
- Molecular Weight:112.13
InChIKey: GVKYFODEMNCLGS-ONEGZZNKSA-N
SMILES: O=C/C=C/C(CC)=O
Biological Activity: 4-OHE ((E)-4-Oxo-2-hexenal) is a mutagen formed by omega-3 lipid peroxidation. 4-OHE reacts with deoxyguanosine, deoxycytidine and 5-methyldeoxycytidine to form covalent adducts. 4-OHE induces apoptosis and exhibits genotoxicity. 4-OHE inhibits the growth of Gram-positive and Gram-negative bacteria, which correlates with its electrophilic reactivity towards nucleophilic biomolecules. 4-OHE is a chemical defense component of Dolycoris baccarum (sloe bug), and acts as a deterrent and toxin against insect predators[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-OHE | 98.97% | 4-OHE ((E)-4-Oxo-2-hexenal) is a mutagen formed by omega-3 lipid peroxidation. 4-OHE reacts with deoxyguanosine, deoxycytidine and 5-methyldeoxycytidine to form covalent adducts. 4-OHE induces apoptosis and exhibits genotoxicity. 4-OHE inhibits the growth of Gram-positive and Gram-negative bacteria, which correlates with its electrophilic reactivity towards nucleophilic biomolecules. 4-OHE is a chemical defense component of Dolycoris baccarum (sloe bug), and acts as a deterrent and toxin against insect predators. | ||||||||||||||||||||
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References
- [1]. Kasai H, et al. 4-oxo-2-hexenal, a mutagen formed by omega-3 fat peroxidation, causes DNA adduct formation in mouse organs. Ind Health. 2005;43(4):699-701. [Content Brief]
- [2]. Noge K, et al. Antibacterial activity of 4-oxo-(E)-2-hexenal from adults and nymphs of the heteropteran, Dolycoris baccarum (Heteroptera: Pentatomidae). Biosci Biotechnol Biochem. 2012;76(10):1975-1978. [Content Brief]
- [3]. Kasai H, et al. 4-oxo-2-hexenal, a mutagen formed by omega-3 fat peroxidation: occurrence, detection and adduct formation. Mutat Res. 2008;659(1-2):56-59. [Content Brief]
