2497686-66-3
Chemical Structure
RMS3
- CAS No.: 2497686-66-3
- Formula:C38H39F3N2O6
- Molecular Weight:676.72
IUPAC Name: (11R,31S)-16,36,37-trimethoxy-12,32-dimethyl-54-(trifluoromethoxy)-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphane
InChIKey: GXYCRLYOVMMTJP-WDYNHAJCSA-N
SMILES: COC1=C2C3=C(C=C1OC)CCN(C)[C@@]3([H])CC4=CC=C(OC(F)(F)F)C(OC5=CC=C(C[C@]6([H])C7=CC(O2)=C(C=C7CCN6C)OC)C=C5)=C4
Biological Activity: RMS3, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS3 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS3 has strong anticancer property[1].
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RMS3 | RMS3, a tetrandrine analogue, is a potent P-glycoprotein (P-gp) inhibitor. RMS3 has markedly antiproliferative and cytotoxic effects on cancer cells. RMS3 causes PARP cleavage, a marker for cells undergoing apoptosis. RMS3 has strong anticancer property. | |||||||||||||||||||||
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Keywords
