2521285-05-0
2521285-05-0
Chemical Structure
Sevabertinib
Synonym(s): BAY 2927088
- CAS No.: 2521285-05-0
- Formula:C24H25ClN4O5
- Molecular Weight:484.93
InChIKey: VYQVHWNNPKOJEA-AWEZNQCLSA-N
SMILES: O=C(NCC1)C2=C1NC(C3=CC=NC=C3OC[C@@H]4COCCO4)=C2NC5=C(C(Cl)=CC=C5)OC
Biological Activity: Sevabertinib (BAY 2927088) is an orally active and reversible dual EGFR-HER2 inhibitor (IC50 <0.5 nM for wild-type HER2, HER2 A775insYVMA, wild-type EGFR, and EGFR D770_N771insSVD). Sevabertinib has anticancer activity against lung cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sevabertinib | 99.90% | Sevabertinib (BAY 2927088) is an orally active and reversible dual EGFR-HER2 inhibitor (IC50 <0.5 nM for wild-type HER2, HER2 A775insYVMA, wild-type EGFR, and EGFR D770_N771insSVD). Sevabertinib has anticancer activity against lung cancer. | ||||||||||||||||||||
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References
Keywords
