253174-92-4
253174-92-4
Chemical Structure
BMS-262084
- CAS No.: 253174-92-4
- Formula:C18H31N7O5
- Molecular Weight:425.48
IUPAC Name: (2S,3R)-1-(4-(tert-butylcarbamoyl)piperazine-1-carbonyl)-3-(3-guanidinopropyl)-4-oxoazetidine-2-carboxylic acid
InChIKey: MFTQITSPGQORDA-NEPJUHHUSA-N
SMILES: CC(C)(NC(N1CCN(C(N2[C@H](C(O)=O)[C@@H](CCCNC(N)=N)C2=O)=O)CC1)=O)C
Biological Activity: BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC50 of 2.8 nM against human factor XIa. BMS-262084 also inhibits human tryptase (IC50=5 nM). BMS-262084 exhibits antithrombotic effects[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMS-262084 | 98.41% | BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC50 of 2.8 nM against human factor XIa. BMS-262084 also inhibits human tryptase (IC50=5 nM). BMS-262084 exhibits antithrombotic effects. | ||||||||||||||||||||
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References
- [1]. Schumacher WA, et, al. Antithrombotic and hemostatic effects of a small molecule factor XIa inhibitor in rats. Eur J Pharmacol. 2007 Sep 10;570(1-3):167-74. [Content Brief]
- [2]. Qian X, et, al. A stereoselective synthesis of BMS-262084, an azetidinone-based tryptase inhibitor. J Org Chem. 2002 May 31;67(11):3595-600. [Content Brief]
