2538149-57-2
Chemical Structure
PDE5-IN-3
- CAS No.: 2538149-57-2
- Formula:C21H14BrN5O2
- Molecular Weight:448.27
IUPAC Name: 1-(4-bromophenyl)-6-(2-methoxyquinolin-3-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
InChIKey: VEWWTIYTUWYUOJ-UHFFFAOYSA-N
SMILES: O=C1C2=C(N(C3=CC=C(Br)C=C3)N=C2)N=C(C4=CC5=CC=CC=C5N=C4OC)N1
Biological Activity: PDE5-IN-3 (compound 11j) is a potent PDE5 inhibitor with an IC50 of 1.57 nM. PDE5-IN-3 shows moderate EGFR inhibition with IC50 of 5.827 µM. PDE5-IN-3 significantly inhibits the Wnt/β-catenin pathway (IC50=1286.96 ng/mL). PDE5-IN-3 induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells. PDE5-IN-3 has strong antitumor activity[1].
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PDE5-IN-3 | PDE5-IN-3 (compound 11j) is a potent PDE5 inhibitor with an IC50 of 1.57 nM. PDE5-IN-3 shows moderate EGFR inhibition with IC50 of 5.827 µM. PDE5-IN-3 significantly inhibits the Wnt/β-catenin pathway (IC50=1286.96 ng/mL). PDE5-IN-3 induces the intrinsic apoptotic mitochondrial pathway in HepG2 cells. PDE5-IN-3 has strong antitumor activity. | |||||||||||||||||||||
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