2561413-77-0
2561413-77-0
Chemical Structure
WF-47-JS03
- CAS No.: 2561413-77-0
- Formula:C30H38N6O2
- Molecular Weight:514.66
IUPAC Name: 3-(3,4-dimethoxyphenyl)-N5-(1,2,2,6,6-pentamethylpiperidin-4-yl)-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diamine
InChIKey: YRBWLEAMGAGYBK-UHFFFAOYSA-N
SMILES: NC(N1C(N=C2NC3CC(C)(C)N(C)C(C)(C)C3)=C(C4=CC(OC)=C(OC)C=C4)C=N1)=C2C5=CC=CC=C5
Biological Activity: WF-47-JS03 is a potent, selective and brain-penetrantRET kinase inhibitor with IC50s of 1.7 nM and 5.3 nM for KIF5B-RET transfected Ba/F3 cells and CCDC6-RET transfected LC-2/ad lung cancer cells, respectively. WF-47-JS03 demonstrates >500-fold selectivity against kinase insert domain receptor (KDR)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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WF-47-JS03 | 99.63% | WF-47-JS03 is a potent, selective and brain-penetrantRET kinase inhibitor with IC50s of 1.7 nM and 5.3 nM for KIF5B-RET transfected Ba/F3 cells and CCDC6-RET transfected LC-2/ad lung cancer cells, respectively. WF-47-JS03 demonstrates >500-fold selectivity against kinase insert domain receptor (KDR). | ||||||||||||||||||||
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