2568523-72-6
2568523-72-6
Chemical Structure
PROTAC SMARCA2 degrader-6
- CAS No.: 2568523-72-6
- Formula:C56H70N12O5S
- Molecular Weight:1023.30
InChIKey: UEPPXXSTXCINPY-NBOILGNBSA-N
SMILES: O=C([C@H]1N(C[C@H](O)C1)C([C@@H](NC([C@H]2C[C@]3(C[C@H](CN4CCC(CC4)C5=CN=C(N6C7CN(CC6CC7)C8=C(N)N=NC(C9=CC=CC=C9O)=C8)N=C5)C3)C2)=O)C(C)(C)C)=O)NCC%10=CC=C(C%11=C(C)N=CS%11)C=C%10
Biological Activity: PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment[1].
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PROTAC SMARCA2 degrader-6 | PROTAC SMARCA2 degrader-6 (compound I-427) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment. | |||||||||||||||||||||
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References
Keywords
