2570251-63-5
2570251-63-5
Chemical Structure
SIAIS001
- CAS No.: 2570251-63-5
- Formula:C48H51N7O4
- Molecular Weight:789.96
InChIKey: OGAOHACYLUBWJQ-UHFFFAOYSA-N
SMILES: N#CC1=CC(NC2=C3C(C4=C(C2(C)C)C=C(N5CCC(CC5)N6CCN(CCCC#CC7=CC=CC8=C7CN(C9C(NC(CC9)=O)=O)C8=O)CC6)C(CC)=C4)=O)=C3C=C1
Biological Activity: SIAIS001 is a CRBN-dependent ALK PROTAC degrader with a DC50 of 3.9 nM. SIAIS001 induces ALK protein degradation via the ubiquitin-proteasome system. SIAIS001 induces G1/S phase cell cycle arrest and inhibits proliferation of cancer cells. SIAIS001 can be used for the research of anaplastic large-cell lymphomas[1].
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SIAIS001 | SIAIS001 is a CRBN-dependent ALK PROTAC degrader with a DC50 of 3.9 nM. SIAIS001 induces ALK protein degradation via the ubiquitin-proteasome system. SIAIS001 induces G1/S phase cell cycle arrest and inhibits proliferation of cancer cells. SIAIS001 can be used for the research of anaplastic large-cell lymphomas. | |||||||||||||||||||||
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