2571068-74-9
2571068-74-9
Chemical Structure
YK-2168
- CAS No.: 2571068-74-9
- Formula:C16H18ClN5
- Molecular Weight:315.80
InChIKey: HXJZLLNYPHBNSR-UHFFFAOYSA-N
SMILES: ClC1=CN=C(NC(C2CCNCC2)=C3)C3=C1C4=CN(C)N=C4
Biological Activity: YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. YK-2168 inhibits phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. YK-2168 induces apoptosis in tumor cells, suppresses expression of CDK9-regulated genes including MYC and Mcl1, and inhibits tumor growth in CDX mice models. YK-2168 can be used for the research of cancer, such as leukemia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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YK-2168 | 98.05% | YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. YK-2168 inhibits phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. YK-2168 induces apoptosis in tumor cells, suppresses expression of CDK9-regulated genes including MYC and Mcl1, and inhibits tumor growth in CDX mice models. YK-2168 can be used for the research of cancer, such as leukemia. | ||||||||||||||||||||
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References
Keywords
