2574545-45-0
2574545-45-0
Chemical Structure
ATR-IN-4
- CAS No.: 2574545-45-0
- Formula:C18H20N8O
- Molecular Weight:364.40
IUPAC Name: (R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazin-2-yl)morpholine
InChIKey: BUTVLOCHWATRAS-GFCCVEGCSA-N
SMILES: CN1C(C2=CC(N3[C@@H](COCC3)C)=NN4C2=CN=C4C5=NNC=C5)=CC=N1
Biological Activity: ATR-IN-4 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ATR-IN-4 | 98.35% | ATR-IN-4 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13). | ||||||||||||||||||||
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