261521-21-5
Chemical Structure
SFNGGP-NH2
- CAS No.: 261521-21-5
- Formula:C25H36N8O8
- Molecular Weight:576.60
InChIKey: PFUDDJZDHHDVLA-XSLAGTTESA-N
SMILES: OC[C@H](N)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(N)=O)C(NCC(NCC(N2[C@@H](CCC2)C(N)=O)=O)=O)=O)=O)=O
Biological Activity: SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.)
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SFNGGP-NH2 | SFNGGP-NH2 is a biological active peptide. (PAR-3 is a high-affinity thrombin receptor. PAR-3 mRNA is expressed in the cutaneous mast cells of humans. Protease-Activated Receptors (PARs) have been studied for their roles in itch and their itch-associated response through histamine-dependent/independent pathways have been reported. PAR-3 has been shown not to induce itching alone but possibly in conjunction with PAR-4. Co-expression of PAR-3 and PAR-4 enhances thrombin action suggesting that PAR-3 alone does not mediate transmembrane signaling but instead functions as a cofactor to activate PAR-4.) | |||||||||||||||||||||
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