262425-59-2
262425-59-2
Chemical Structure
PBPE hydrochloride
- CAS No.: 262425-59-2
- Formula:C19H24ClNO
- Molecular Weight:317.85
InChIKey: ZWMCGZQOUYHEIQ-UHFFFAOYSA-N
SMILES: C1(OCCN2CCCC2)=CC=C(CC3=CC=CC=C3)C=C1.Cl
Biological Activity: PBPE hydrochloride is a derivative of tamoxifen (HY-13757A) and a selective ligand for the anti-estrogen binding site (AEBS), the binding affinities (Ki) of PBPE hydrochloride and MBPE to AEBS are 8.79 and 17.57 nM, respectively[1][2].
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PBPE hydrochloride | 99.30% | PBPE hydrochloride is a derivative of tamoxifen (HY-13757A) and a selective ligand for the anti-estrogen binding site (AEBS), the binding affinities (Ki) of PBPE hydrochloride and MBPE to AEBS are 8.79 and 17.57 nM, respectively. | ||||||||||||||||||||
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PBPE hydrochloride (Standard) | PBPE hydrochloride (Standard) is the analytical standard of PBPE (hydrochloride) (HY-10830A). This product is intended for research and analytical applications. PBPE hydrochloride is a derivative of tamoxifen (HY-13757A) and a selective ligand for the anti-estrogen binding site (AEBS), the binding affinities (Ki) of PBPE hydrochloride and MBPE to AEBS are 8.79 and 17.57 nM, respectively. | |||||||||||||||||||||
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References
- [1]. B Kedjouar, et al. Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor. Biochem Pharmacol. 1999 Dec 15;58(12):1927-39. [Content Brief]
- [2]. Florence Dalenc, et al. Farnesyl-transferase inhibitor R115,777 enhances tamoxifen inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways. Breast Cancer Res. 2005;7(6):R1159-67. [Content Brief]
