2625406-61-1
Chemical Structure
KMT9-IN-1
- CAS No.: 2625406-61-1
- Formula:C36H47ClFN7O5
- Molecular Weight:712.25
InChIKey: TYNTYAFAOQSHAG-MOGKEIEASA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](CN(CC[C@H](N)C(OCC)=O)CCCNCCC2=CC=C(OC3=CC=C(Cl)C=C3)C(F)=C2)C[C@H]1N4C=CC5=C(NC)N=CN=C54
Biological Activity: KMT9-IN-1 (Compound 8) is a KMT9 inhibitor and the ethyl ester prodrug of compound 7b. KMT9-IN-1 releases the active form 7b via esterases in cells. KMT9-IN-1 targets KMT9 in cells and reduces H4K12me1 levels. KMT9-IN-1 has antitumor activity against colon cancer. KMT9-IN-1 can be used in the research of prostate cancer and hepatocellular carcinoma[1].
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KMT9-IN-1 | KMT9-IN-1 (Compound 8) is a KMT9 inhibitor and the ethyl ester prodrug of compound 7b. KMT9-IN-1 releases the active form 7b via esterases in cells. KMT9-IN-1 targets KMT9 in cells and reduces H4K12me1 levels. KMT9-IN-1 has antitumor activity against colon cancer. KMT9-IN-1 can be used in the research of prostate cancer and hepatocellular carcinoma. | |||||||||||||||||||||
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Keywords
