2628506-54-5
2628506-54-5
Chemical Structure
PD-1/PD-L1-IN-9
- CAS No.: 2628506-54-5
- Formula:C22H24N2O2
- Molecular Weight:348.44
IUPAC Name: 2-(((2-methoxy-6-(2-methyl-[1,1'-biphenyl]-3-yl)pyridin-3-yl)methyl)amino)ethan-1-ol
InChIKey: ANLIWBJMRQBWBM-UHFFFAOYSA-N
SMILES: CC1=C(C=CC=C1C2=CC=CC=C2)C3=NC(OC)=C(C=C3)CNCCO
Biological Activity: PD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 also exhibits significant in vivo antitumor activity in a CT26 mouse model[1].
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PD-1/PD-L1-IN-9 | 99.59% | PD-1/PD-L1-IN-9 is a potent and orally active inhibitor of PD-1/PD-L1 interaction, with an IC50 of 3.8 nM. PD-1/PD-L1-IN-9 can enhance the killing activity of tumor cells by immune cells. PD-1/PD-L1-IN-9 also exhibits significant in vivo antitumor activity in a CT26 mouse model. | ||||||||||||||||||||
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