2641013-11-6
2641013-11-6
Chemical Structure
Progranulin modulator-1
- CAS No.: 2641013-11-6
- Formula:C21H21F2N3O
- Molecular Weight:369.41
InChIKey: YFWHTUPMKHSVCF-OALUTQOASA-N
SMILES: FC1=CC=C(C=C1)[C@@H]2N(C3=N[C@H](C4(CNC4)F)CO3)CCC5=CC=CC=C52
Biological Activity: Progranulin modulator-1 (Compound 60) is an orally active enhancer of progranulin (PGRN) secretion. Progranulin modulator-1 enhances the potency of BV-2 cell to increase PGRN levels, has inhibitory effect on hERG and Low cytotoxicity, the PGRN EC50 and hERG IC50 were 83 and 3100 nM, respectively[1].
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Progranulin modulator-1 | Progranulin modulator-1 (Compound 60) is an orally active enhancer of progranulin (PGRN) secretion. Progranulin modulator-1 enhances the potency of BV-2 cell to increase PGRN levels, has inhibitory effect on hERG and Low cytotoxicity, the PGRN EC50 and hERG IC50 were 83 and 3100 nM, respectively. | |||||||||||||||||||||
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