2642079-89-6
2642079-89-6
Chemical Structure
NXE0041178
- CAS No.: 2642079-89-6
- Formula:C19H14F4N4O
- Molecular Weight:390.33
InChIKey: VASPFLVEEOBQOS-UHFFFAOYSA-N
SMILES: O=C1NCCC2=C1C=NN2C3=CC(CC4=CC(F)=CC(C(F)(F)F)=C4)=NC=C3
Biological Activity: NXE0041178 is an orally active and BBB-penetrant full GPR52 agonist, with a pEC50 of 7.5 for human GPR52 and an EC50 of 27.5 nM (pEC50 = 7.55) for rat GPR52. NXE0041178 shows no significant inhibition on hERG, hNaV1.5 and cytochrome P450 isoforms. NXE0041178 can reduce d-amphetamine-induced hyperactivity in rats. NXE0041178 can be used for research of Neurological disease[1][2].
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NXE0041178 | 99.97% | NXE0041178 is an orally active and BBB-penetrant full GPR52 agonist, with a pEC50 of 7.5 for human GPR52 and an EC50 of 27.5 nM (pEC50 = 7.55) for rat GPR52. NXE0041178 shows no significant inhibition on hERG, hNaV1.5 and cytochrome P450 isoforms. NXE0041178 can reduce d-amphetamine-induced hyperactivity in rats. NXE0041178 can be used for research of Neurological disease. | ||||||||||||||||||||
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References
- [1]. Poulter S, et al. The Identification of GPR52 Agonist HTL0041178, a Potential Therapy for Schizophrenia and Related Psychiatric Disorders. ACS Med Chem Lett. 2023;14(4):499-505. Published 2023 Mar 14. [Content Brief]
- [2]. Poulter S, et al. Preclinical pharmacokinetics, metabolism, and disposition of NXE0041178, a novel orally bioavailable agonist of the GPR52 receptor with potential for treatment of schizophrenia and related psychiatric disorders. Xenobiotica. 2025;55(3):151-166. [Content Brief]
Keywords
