2651196-71-1
2651196-71-1
Chemical Structure
CDK12-IN-6
- CAS No.: 2651196-71-1
- Formula:C20H21F2N9
- Molecular Weight:425.44
IUPAC Name: 8-cyclopropyl-N-((6,7-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-2-(piperazin-1-yl)pyrazolo[1,5-a][1,3,5]triazin-4-amine
InChIKey: BQWUTZRKMIAITL-UHFFFAOYSA-N
SMILES: FC1=C2C(N=C(CNC3=NC(N4CCNCC4)=NC5=C(C6CC6)C=NN53)N2)=CC=C1F
Biological Activity: CDK12-IN-6, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 1.19 μM at high ATP (2 mM). CDK12-IN-6 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CDK12-IN-6 | 99.15% | CDK12-IN-6, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 1.19 μM at high ATP (2 mM). CDK12-IN-6 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1). | ||||||||||||||||||||
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References
Keywords
