2651200-35-8
2651200-35-8
Chemical Structure
CDK12-IN-5
- CAS No.: 2651200-35-8
- Formula:C18H15F5N8O
- Molecular Weight:454.36
IUPAC Name: N-((6,7-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-2-morpholino-8-(trifluoromethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine
InChIKey: XFZQHKMIWRKKCU-UHFFFAOYSA-N
SMILES: FC(C1=C2N(N=C1)C(NCC3=NC4=CC=C(F)C(F)=C4N3)=NC(N5CCOCC5)=N2)(F)F
Biological Activity: CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CDK12-IN-5 | 98.03% | CDK12-IN-5, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 23.9 nM at high ATP (2 mM). CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1). | ||||||||||||||||||||
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References
Keywords
