2663989-04-4
Chemical Structure
Cap-dependent endonuclease-IN-10
- CAS No.: 2663989-04-4
- Formula:C25H18F2N4O5S
- Molecular Weight:524.50
IUPAC Name: (R)-12-((S)-9,10-difluoro-1-oxo-6,11-dihydro-1H-2-thia-11a-azadibenzo[cd,g]azulen-6-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione
InChIKey: FOQDXMRBJYEATR-QUCCMNQESA-N
SMILES: FC1=C2C([C@@](N3N4C(C(N5[C@@]3([H])COCC5)=O)=C(C(C=C4)=O)O)([H])C6=CC=CC7=C6N(C(S7)=O)C2)=CC=C1F
Biological Activity: Cap-dependent endonuclease-IN-10 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-10 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo pharmacokinetic and in vivo pharmacodynamic properties, and better hepatic microsomal stability. Cap-dependent endonuclease-IN-10 has the potential for the research of viral infections (including influenza A, influenza B and influenza C) (extracted from patent WO2021129799A1, compound 1-1)[1].
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Cap-dependent endonuclease-IN-10 | Cap-dependent endonuclease-IN-10 is a potent inhibitor of cap-dependent endonuclease (CEN). Not only can Cap-dependent endonuclease-IN-10 inhibit influenza virus well, but also has lower cytotoxicity, better in vivo pharmacokinetic and in vivo pharmacodynamic properties, and better hepatic microsomal stability. Cap-dependent endonuclease-IN-10 has the potential for the research of viral infections (including influenza A, influenza B and influenza C) (extracted from patent WO2021129799A1, compound 1-1). | |||||||||||||||||||||
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