26766-35-8
26766-35-8
Chemical Structure
LY43578
- CAS No.: 26766-35-8
- Formula:C17H12Cl2N2O
- Molecular Weight:331.20
IUPAC Name: bis(4-chlorophenyl)(pyrimidin-5-yl)methanol
InChIKey: CSRYTZCLFTYZLS-UHFFFAOYSA-N
SMILES: OC(C1=CC=C(C=C1)Cl)(C2=CN=CN=C2)C3=CC=C(C=C3)Cl
Biological Activity: LY43578 is an orally active aromatase inhibitor. LY43578 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 0.3 and 5 μΜ, respectively. LY43578 can be used for neurological disorder study[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LY43578 | 99.76% | LY43578 is an orally active aromatase inhibitor. LY43578 inhibits P-450-dependent p-nitroanisole O-demethylation and ethylmorphine N-demethylation in hepatic microsomes isolated from rat, with the IC50 of 0.3 and 5 μΜ, respectively. LY43578 can be used for neurological disorder study. | ||||||||||||||||||||
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References
- [1]. Lindstrom TD, et al. Disposition of the aromatase inhibitor LY56110 and associated induction and inhibition studies in rats, dogs, and monkeys. Fundam Appl Toxicol. 1987;8(4):595-604. [Content Brief]
- [2]. Gonzalez MI, et al. Injection of an aromatase inhibitor after the critical period of sexual differentiation. Pharmacol Biochem Behav. 1994;47(1):183-186. [Content Brief]
Keywords
