2696407-32-4
Chemical Structure
ZA18
- CAS No.: 2696407-32-4
- Formula:C29H30N4O
- Molecular Weight:450.57
IUPAC Name: [1,1'-biphenyl]-4-yl(9-(2-(diethylamino)ethyl)-2-methyl-9H-benzo[d]imidazo[1,2-a]imidazol-3-yl)methanone
InChIKey: BOTAUGIOASSDMJ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=CC=CC=C2)C=C1)C3=C(C)N=C4N(CCN(CC)CC)C5=CC=CC=C5N43
Biological Activity: ZA18 is a selective TRPM2 channel inhibitor, with an IC50 value of 6.2 μM. ZA18 can effectively suppress intracellular Ca2+ overload triggered by TRPM2 channel activation. ZA18 significantly reduce the mortality of SH-SY5Y cells induced by H2O2. ZA18 can be used for the study of ischemia-reperfusion injury, inflammation, or other neurodegenerative diseases[1].
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ZA18 | 99.72% | ZA18 is a selective TRPM2 channel inhibitor, with an IC50 value of 6.2 μM. ZA18 can effectively suppress intracellular Ca2+ overload triggered by TRPM2 channel activation. ZA18 significantly reduce the mortality of SH-SY5Y cells induced by H2O2. ZA18 can be used for the study of ischemia-reperfusion injury, inflammation, or other neurodegenerative diseases. | ||||||||||||||||||||
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Keywords
