2701283-32-9
2701283-32-9
Chemical Structure
(Rac)-Nebivolol-d4 hydrochloride
Synonym(s): (Rac)-R 065824-d4 hydrochloride
- CAS No.: 2701283-32-9
- Formula:C22H22D4ClF2NO4
- Molecular Weight:445.92
IUPAC Name: 2,2'-azanediylbis(1-(6-fluorochroman-2-yl)ethan-2,2-d2-1-ol) hydrochloride
InChIKey: JWEXHQAEWHKGCW-ZYMFQSNRSA-N
SMILES: [2H]C(NC([2H])(C(C1CCC2=C(O1)C=CC(F)=C2)O)[2H])(C(C3CCC4=CC(F)=CC=C4O3)O)[2H].Cl
Biological Activity: (Rac)-Nebivolol-d4 hydrochloride is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1-adrenergic receptor with an IC50 of 0.8 nM[1][2][3].
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(Rac)-Nebivolol-d4 hydrochloride | (Rac)-Nebivolol-d4 hydrochloride is a labelled racemic Nebivolol. Nebivolol selectively inhibits β1-adrenergic receptor with an IC50 of 0.8 nM. | |||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Brehm BR, et al. Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovasc Res. 2001 Feb 1;49(2):430-9. [Content Brief]
- [3]. Mercanoglu G, et al. The effects of nebivolol on apoptosis in a rat infarct model. Circ J. 2008 Apr;72(4):660-70. [Content Brief]
