2702673-78-5
2702673-78-5
Chemical Structure
PTP1B-IN-3 diammonium
- CAS No.: 2702673-78-5
- Formula:C12H13BrF2N3O3P
- Molecular Weight:396.12
IUPAC Name: ((3-bromo-7-cyanonaphthalen-2-yl)difluoromethyl)phosphonic acid, diammonia salt
InChIKey: DKKOXAMRGUYZIQ-UHFFFAOYSA-N
SMILES: BrC1=C(C(F)(P(O)(O)=O)F)C=C2C(C=CC(C#N)=C2)=C1.N.N
Biological Activity: PTP1B-IN-3 diammonium is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 diammonium has antidiabetic and anticancer effects[1][2].
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PTP1B-IN-3 diammonium | ≥95.0% | PTP1B-IN-3 diammonium is a potent and orally active PTP1B inhibitor with IC50s of 120 nM for both PTP1B and TCPTP. PTP1B-IN-3 diammonium has antidiabetic and anticancer effects. | ||||||||||||||||||||
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References
- [1]. Yongxin Han, et al. Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3200-5. [Content Brief]
- [2]. Price N, et al. Safety and Efficacy of a Topical Sodium Channel Inhibitor (TV-45070) in Patients With Postherpetic Neuralgia (PHN): A Randomized, Controlled, Proof-of-Concept, Crossover Study, With a Subgroup Analysis of the Nav1.7 R1150W Genotype. Clin J Pain. 2017 Apr;33(4):310-318. [Content Brief]
