2712126-51-5
Chemical Structure
Cystamine-d8 dihydrochloride
- CAS No.: 2712126-51-5
- Formula:C4H6D8Cl2N2S2
- Molecular Weight:233.25
IUPAC Name: 2,2'-disulfanediylbis(ethan-1,1,2,2-d4-1-amine) dihydrochloride
InChIKey: YUFRRMZSSPQMOS-VHGLFXLXSA-N
SMILES: NC([2H])([2H])C([2H])([2H])SSC([2H])([2H])C([2H])([2H])N.Cl.Cl
Biological Activity: Cystamine-d8 (dihydrochloride） is the deuterium labeled Cystamine (dihydrochloride）[1]. Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD)[2][3][4].
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Cystamine-d8 dihydrochloride | Cystamine-d8 (dihydrochloride） is the deuterium labeled Cystamine (dihydrochloride）. Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD). | |||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Mathieu Lesort, et al. Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders. J Biol Chem. 2003 Feb 7;278(6):3825-30. [Content Brief]
- [3]. Alpaslan Dedeoglu, et al. Therapeutic effects of cystamine in a murine model of Huntington's disease. J Neurosci. 2002 Oct 1522(20):8942-50. [Content Brief]
- [4]. Thomas M Jeitner, et al. Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo. Biosci Rep. 2018 Sep 538(5):BSR20180691. [Content Brief]
Keywords
