2716184-87-9
Chemical Structure
CSF1R-IN-6
- CAS No.: 2716184-87-9
- Formula:C20H18N8O3
- Molecular Weight:418.41
IUPAC Name: 1,2-dimethyl-N-(5-((6-(1-methyl-1H-pyrazol-4-yl)pyrimidin-4-yl)oxy)pyridin-2-yl)-6-oxo-1,6-dihydropyrimidine-5-carboxamide
InChIKey: JUXLGMUXLITEOM-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(C)N(C)C1=O)NC2=NC=C(C=C2)OC3=NC=NC(C4=CN(C)N=C4)=C3
Biological Activity: CSF1R-IN-6 is a potent inhibitor of CSF1R. CSF-1R is expressed in macrophages, and the survival and differentiation of macrophages depends on the CSF-1/CSF-1R signaling pathway. CSF1R-IN-6 affects the exchange of inflammatory factors between TAMs and glioma cells. CSF1R-IN-6 has the potential for the research of cancer disease (extracted from patent WO2021197276A1, compound 5)[1].
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CSF1R-IN-6 | CSF1R-IN-6 is a potent inhibitor of CSF1R. CSF-1R is expressed in macrophages, and the survival and differentiation of macrophages depends on the CSF-1/CSF-1R signaling pathway. CSF1R-IN-6 affects the exchange of inflammatory factors between TAMs and glioma cells. CSF1R-IN-6 has the potential for the research of cancer disease (extracted from patent WO2021197276A1, compound 5). | |||||||||||||||||||||
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Keywords
