2725770-20-5
2725770-20-5
Chemical Structure
RET-IN-5
- CAS 番号: 2725770-20-5
- Formula:C29H26FN9O
- Molecular Weight:535.57
IUPAC Name: (S)-6-(2-cyano-2-methylpropoxy)-4-(6-((1-(6-(4-fluoro-1H-pyrazol-1-yl)pyridin-3-yl)ethyl)(methyl)amino)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
InChIKey: YLKJBUGPEZIIKF-IBGZPJMESA-N
SMILES: N#CC1=C2C(C3=CN=C(N(C)[C@H](C4=CN=C(N5C=C(C=N5)F)C=C4)C)C=C3)=CC(OCC(C)(C)C#N)=CN2N=C1
Biological Activity: RET-IN-5 is a potent RET (rearranged during transfection) inhibitor with an IC50s of 0.4 nM and 135.1 nM for RET and VEGFR2, respectively (WO2021213476A1, compound 18)[1].
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RET-IN-5 | RET-IN-5 is a potent RET (rearranged during transfection) inhibitor with an IC50s of 0.4 nM and 135.1 nM for RET and VEGFR2, respectively (WO2021213476A1, compound 18). | |||||||||||||||||||||
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