2728291-29-8
Chemical Structure
P2Y14R antagonist 1
- CAS No.: 2728291-29-8
- Formula:C15H12BrN3O2
- Molecular Weight:346.18
InChIKey: OMPWLXOPMAMOCA-UHFFFAOYSA-N
SMILES: O=C(NC1=CC2=C(C=C1)N=CN2)COC3=CC=C(C=C3)Br
Biological Activity:
P2Y14R antagonist 1 (compound I-17) is a selective P2Y14R antagonist with an IC50 of 0.6 nM. It exhibits potent P2Y14R antagonistic activity, both in vitro and in vivo efficacy, and favorable pharmacokinetic profiles. P2Y14R antagonist 1 reduces the release of inflammatory factors and cell pyroptosis through the NOD-like receptor family pyrin domain-containing 3 (NLRP3)/gasdermin D (GSDMD) signaling pathway. P2Y14R antagonist 1 holds promise for research in the field of acute gouty arthritis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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P2Y14R antagonist 1 | 98.76% | P2Y14R antagonist 1 (compound I-17) is a selective P2Y14R antagonist with an IC50 of 0.6 nM. It exhibits potent P2Y14R antagonistic activity, both in vitro and in vivo efficacy, and favorable pharmacokinetic profiles. P2Y14R antagonist 1 reduces the release of inflammatory factors and cell pyroptosis through the NOD-like receptor family pyrin domain-containing 3 (NLRP3)/gasdermin D (GSDMD) signaling pathway. P2Y14R antagonist 1 holds promise for research in the field of acute gouty arthritis. |
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