2738550-24-6
2738550-24-6
Chemical Structure
M3686
- CAS No.: 2738550-24-6
- Formula:C21H18F3N5O2
- Molecular Weight:429.40
InChIKey: PCCIBQMLPNTFDC-HNNXBMFYSA-N
SMILES: O[C@@H]1CN(C(C2=CC3=C(N(C4=CC=C(C(F)(F)F)C=C4)C5=NN(C)N=C53)C=C2)=O)CC1
Biological Activity: M3686 (Compound 29) is a potent, selective TEAD1 inhibitor with an IC50 value of 51 nM. M3686 also shows weaker binding activity on TEAD3. M3686 potently inhibits cell viability against YAP-dependent NCI-H226 cell line with an IC50 value of 0.06 uM. M3686 shows strong anti-tumor effects in the NCI-H226 xenograft model[1].
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M3686 | M3686 (Compound 29) is a potent, selective TEAD1 inhibitor with an IC50 value of 51 nM. M3686 also shows weaker binding activity on TEAD3. M3686 potently inhibits cell viability against YAP-dependent NCI-H226 cell line with an IC50 value of 0.06 uM. M3686 shows strong anti-tumor effects in the NCI-H226 xenograft model. | |||||||||||||||||||||
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