2739844-34-7
2739844-34-7
Chemical Structure
HPK1-IN-3
- CAS No.: 2739844-34-7
- Formula:C23H22F4N6O2
- Molecular Weight:490.45
IUPAC Name: 4-((2-fluoro-6-(trifluoromethyl)phenyl)amino)-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)pyrimidine-5-carboxamide
InChIKey: RZLXOEIALAVGKH-UHFFFAOYSA-N
SMILES: COC1=C(NC2=NC=C(C(N)=O)C(NC3=C(F)C=CC=C3C(F)(F)F)=N2)C=C4CN(C)CCC4=C1
Biological Activity: HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC50 of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC50 of 108 nM in human peripheral blood mononuclear cells (PBMCs)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HPK1-IN-3 | 98.61% | HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC50 of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC50 of 108 nM in human peripheral blood mononuclear cells (PBMCs). | ||||||||||||||||||||
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