2750414-35-6
Chemical Structure
CCG273441
- CAS No.: 2750414-35-6
- Formula:C26H24ClFN4O3
- Molecular Weight:494.95
IUPAC Name: (R,Z)-3-((4-(2-chloroacetamido)-3,5-dimethyl-1H-pyrrol-2-yl)methylene)-N-(1-(4-fluorophenyl)ethyl)-2-oxoindoline-5-carboxamide
InChIKey: IDWBLFLYQVHAFH-LPKQHDGYSA-N
SMILES: O=C(/C(C1=C2)=C\C3=C(C(NC(CCl)=O)=C(N3)C)C)NC1=CC=C2C(N[C@@H](C4=CC=C(C=C4)F)C)=O
Biological Activity: CCG273441 is a covalent inhibitor of G protein-coupled receptor (GPCR) kinase 5 (GRK5) with an IC50 value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC50=4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent handle[1].
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CCG273441 | 98.78% | CCG273441 is a covalent inhibitor of G protein-coupled receptor (GPCR) kinase 5 (GRK5) with an IC50 value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC50=4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent handle. | ||||||||||||||||||||
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Keywords
