2756736-34-0
2756736-34-0
Chemical Structure
Mcl-1-IN-23
- CAS No.: 2756736-34-0
- Formula:C38H39ClN2O4S
- Molecular Weight:655.25
InChIKey: DMYDPMVGDUKMMJ-UHFFFAOYSA-N
SMILES: ClC1=C(C)C=C(OCCCN2C(C)=C(S(=NCC3=CC=C(C4=CC=CC=C4)C=C3)(C5=CC=C(C)C=C5)=O)C(C)=C2C(O)=O)C=C1C
Biological Activity: Mcl-1-IN-23 is a Mcl-1 inhibitor with a Ki value of 0.024 μM. Mcl-1-IN-23 binds directly to Mcl-1 and displaces the pro-apoptotic proteins Bak and Bim from Mcl-1 complexes. Mcl-1-IN-23 induces cell apoptosis, activates caspase-3, promotes PARP cleavage, and exerts antiproliferative activity against cancer cells. Mcl-1-IN-23 can be used for the research of leukemia[1].
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Mcl-1-IN-23 | Mcl-1-IN-23 is a Mcl-1 inhibitor with a Ki value of 0.024 μM. Mcl-1-IN-23 binds directly to Mcl-1 and displaces the pro-apoptotic proteins Bak and Bim from Mcl-1 complexes. Mcl-1-IN-23 induces cell apoptosis, activates caspase-3, promotes PARP cleavage, and exerts antiproliferative activity against cancer cells. Mcl-1-IN-23 can be used for the research of leukemia. | |||||||||||||||||||||
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