2758431-97-7
Chemical Structure
MD13
- CAS No.: 2758431-97-7
- Formula:C35H35N5O8
- Molecular Weight:653.68
IUPAC Name: tert-butyl 2,3-dibromo-4,7-dihydrothieno[2,3-c]pyridine-6(5H)-carboxylate
InChIKey: HAHDZDUOFHMMEA-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(N2C(OC3=CC(O)=CC=C3C2)=O)C=C1)CCCCCCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O
Biological Activity: MD13 is a MIF PROTAC degrader with a DC50 of approximately 100 nM. MD13 induces ubiquitination and degradation of MIF by recruiting the Cereblon Cullin RING E3 ubiquitin ligase complex. MD13 inactivates the MAPK pathway and induces G2/M phase cell cycle arrest. MD13 exhibits antiproliferative effects in 3D tumor spheroid models. MD13 can be used in lung cancer-related research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MD13 | 99.96% | MD13 is a MIF PROTAC degrader with a DC50 of approximately 100 nM. MD13 induces ubiquitination and degradation of MIF by recruiting the Cereblon Cullin RING E3 ubiquitin ligase complex. MD13 inactivates the MAPK pathway and induces G2/M phase cell cycle arrest. MD13 exhibits antiproliferative effects in 3D tumor spheroid models. MD13 can be used in lung cancer-related research. | ||||||||||||||||||||
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Keywords
