2758802-09-2
Chemical Structure
HSD17B13-IN-16
- CAS No.: 2758802-09-2
- Formula:C20H17ClN2O4S
- Molecular Weight:416.88
InChIKey: AUWHJPLXZCPIPY-UHFFFAOYSA-N
SMILES: ClC1=C(O)C=CC(C(NC2=C(C(NCC3=C(OC)C=CC=C3)=O)SC=C2)=O)=C1
Biological Activity: HSD17B13-IN-16 (compound 8) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM and? < 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-16? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis)[1].
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HSD17B13-IN-16 | HSD17B13-IN-16 (compound 8) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of < 0.1 μM and? < 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-16? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis). | |||||||||||||||||||||
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Keywords