2760483-96-1
2760483-96-1
Chemical Structure
Vopimetostat
Synonym(s): TNG-462
- CAS No.: 2760483-96-1
- Formula:C28H36N6O2S
- Molecular Weight:520.69
InChIKey: DHAGMIPSRSPWSH-GAJHUEQPSA-N
SMILES: CCC1=CC(NC(C(N2[C@@H](C3=CC=C(SC(C4CCN(CC4)C)=N5)C5=C3)CC[C@@H](C2)C)=O)=O)=CN=C1N
Biological Activity: TNG-462 is an orally active and selective PRMT5 inhibitor with anti-tumor activity against methylthioadenosine phosphorylase (MTAP) deficiency and/or methylthioadenosine (MTA) accumulation cancers[1][2].
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Vopimetostat | 99.55% | TNG-462 is an orally active and selective PRMT5 inhibitor with anti-tumor activity against methylthioadenosine phosphorylase (MTAP) deficiency and/or methylthioadenosine (MTA) accumulation cancers. | ||||||||||||||||||||
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References
- [1]. Briggs K, et al. TNG462 is a potential best-in-class MTA-cooperative PRMT5 inhibitor for the treatment of MTAP-deleted solid tumors[J]. Cancer Research, 2023, 83(7_Supplement): 4970-4970.
- [2]. Kevin M Cottrell, et al. Piperidin-1- yl-n-pyrydi ne-3-yl-2-oxoacet am ide derivatives useful for the treatment of mtap-deficient and/or mt a-accumulating cancers. Patent WO2022026892A1.
Keywords
