2766352-74-1
Chemical Structure
(R,S,S)-VH032-PEG5-N3
- CAS No.: 2766352-74-1
- Formula:C34H51N7O9S
- Molecular Weight:733.88
IUPAC Name: (2R,4S)-1-((S)-20-azido-2-(tert-butyl)-4-oxo-6,9,12,15,18-pentaoxa-3-azaicosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
InChIKey: IICFWWPVRCNEOK-WTNLLYQRSA-N
SMILES: C([C@@H](NC(COCCOCCOCCOCCOCCN=[N+]=[N-])=O)[C@](C)(C)C)(=O)N1[C@@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](O)C1
Biological Activity: (R,S,S)-VH032-PEG5-N3 is an E3 ligase ligand-linker conjugate comprising a VHL ligand based on VH032 and a 5-unit PEG linker. (R,S,S)-VH032-PEG5-N3 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azido-azynylene cycloaddition (CuAAc) with molecules containing an alkyne group. It can also undergo ring-strain-driven alkyne-azido cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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(R,S,S)-VH032-PEG5-N3 | (R,S,S)-VH032-PEG5-N3 is an E3 ligase ligand-linker conjugate comprising a VHL ligand based on VH032 and a 5-unit PEG linker. (R,S,S)-VH032-PEG5-N3 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azido-azynylene cycloaddition (CuAAc) with molecules containing an alkyne group. It can also undergo ring-strain-driven alkyne-azido cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. | |||||||||||||||||||||
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Keywords
