2766757-56-4
2766757-56-4
Chemical Structure
HW091077
- CAS No.: 2766757-56-4
- Formula:C22H22F4N4O3S
- Molecular Weight:498.49
InChIKey: RILNDXNTTKODDX-AGIUHOORSA-N
SMILES: FC1=C(C2=NC=C(C)S2)C=C(C=C1C(N[C@@H](C3=CN=C(C(F)(F)F)N=C3)C)=O)O[C@@H](C)[C@@H](O)C
Biological Activity: HW091077 is a highly selective P2X3 receptor antagonist with an IC50 of 17 nM. HW091077 blocks ATP-induced calcium influx and cell depolarization to inhibit cough reflex pathways. HW091077 is promising for research of chronic cough[1].
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HW091077 | HW091077 is a highly selective P2X3 receptor antagonist with an IC50 of 17 nM. HW091077 blocks ATP-induced calcium influx and cell depolarization to inhibit cough reflex pathways. HW091077 is promising for research of chronic cough. | |||||||||||||||||||||
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