2768099-61-0
2768099-61-0
Chemical Structure
KRAS G12D inhibitor 25
- CAS. Nr.: 2768099-61-0
- Formula:C56H62ClN11O6
- Molecular Weight:1020.61
InChIKey: CWSKQBIVWAVOQO-STBUXKTCSA-N
SMILES: C=CC(N1CCN(C[C@@H]1CC#N)C2=NC(OC[C@@H]3CCCN(C3)C(C4CCN(CC4)CC5=CC=C(C=C5)N6C(O)=NN=C6C7=C(C=C(C(C(C)C)=C7)O)O)=O)=NC8=C2CCN(C8)C9=C%10C(Cl)=CC=CC%10=CC=C9)=O
Biological Activity: KRAS G12D inhibitor 25 (Compound 148) is an inhibitor for KRAS G12C and HSP90α with IC50 of < 0.1 μM and 0.1-1 μM, respectively. KRAS G12D inhibitor 25 inhibits the proliferation of MIA PaCa-2 and NCI-H358 with EC50 of < 0.1 μM and 0.1-1 μM, respectively. KRAS G12D inhibitor 25 degrades ERBB2 with a DC50 of 0.1-1 μM[1].
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KRAS G12D inhibitor 25 | KRAS G12D inhibitor 25 (Compound 148) is an inhibitor for KRAS G12C and HSP90α with IC50 of < 0.1 μM and 0.1-1 μM, respectively. KRAS G12D inhibitor 25 inhibits the proliferation of MIA PaCa-2 and NCI-H358 with EC50 of < 0.1 μM and 0.1-1 μM, respectively. KRAS G12D inhibitor 25 degrades ERBB2 with a DC50 of 0.1-1 μM. | |||||||||||||||||||||
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