2768613-52-9
Chemical Structure
Tubulin polymerization-IN-6
- CAS No.: 2768613-52-9
- Formula:C19H21NO7
- Molecular Weight:375.37
IUPAC Name: methyl 7-((3,4,5-trimethoxyphenyl)amino)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylate
InChIKey: IOKVAMILFXBKPZ-UHFFFAOYSA-N
SMILES: COC(C1=CC2=C(OCCO2)C=C1NC3=CC(OC)=C(C(OC)=C3)OC)=O
Biological Activity: Tubulin polymerization-IN-6 (compound 5f) is a potent tubulin polymerization inhibitor, with an IC50 of 1.09 μM. Tubulin polymerization-IN-6 inhibits cell migration and tube formation and contributes to the anti-angiogenesis. Tubulin polymerization-IN-6 can greatly inhibit tumor growth on HT29 xenograft Balb/c nude mice[1].
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Tubulin polymerization-IN-6 | Tubulin polymerization-IN-6 (compound 5f) is a potent tubulin polymerization inhibitor, with an IC50 of 1.09 μM. Tubulin polymerization-IN-6 inhibits cell migration and tube formation and contributes to the anti-angiogenesis. Tubulin polymerization-IN-6 can greatly inhibit tumor growth on HT29 xenograft Balb/c nude mice. | |||||||||||||||||||||
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Keywords
