2773925-74-7
Chemical Structure
Mu opioid receptor antagonist 4
- CAS No.: 2773925-74-7
- Formula:C25H28N2O4S
- Molecular Weight:452.57
IUPAC Name: N-((4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-yl)thiophene-3-carboxamide
InChIKey: FUYLSFUBUJCLAY-IXFVLMBFSA-N
SMILES: O[C@]12[C@H]3CC4=C5[C@@]1(CCN3CC6CC6)[C@H]([C@H](CC2)NC(C7=CSC=C7)=O)OC5=C(O)C=C4
Biological Activity: Mu opioid receptor antagonist 4 (compound 31) is a potent and selective μ opioid receptor (MOR) antagonist with a Ki of 0.38 nM and an EC50 of 1.07 nM. Mu opioid receptor antagonist 4 has remarkable CNS antagonism against morphine, and precipitated fewer withdrawal symptoms than Naloxone. Mu opioid receptor antagonist 4 Mu opioid receptor antagonist 4 can be used for researching opioid use disorders (OUD)[1].
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Mu opioid receptor antagonist 4 | Mu opioid receptor antagonist 4 (compound 31) is a potent and selective μ opioid receptor (MOR) antagonist with a Ki of 0.38 nM and an EC50 of 1.07 nM. Mu opioid receptor antagonist 4 has remarkable CNS antagonism against morphine, and precipitated fewer withdrawal symptoms than Naloxone. Mu opioid receptor antagonist 4 Mu opioid receptor antagonist 4 can be used for researching opioid use disorders (OUD). | |||||||||||||||||||||
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