2785430-83-1
2785430-83-1
Chemical Structure
ALK5-IN-27
- CAS No.: 2785430-83-1
- Formula:C25H28N8
- Molecular Weight:440.54
IUPAC Name: N4-(8-methylcinnolin-4-yl)-N2-(3-((4-methylpiperazin-1-yl)methyl)phenyl)pyrimidine-2,4-diamine
InChIKey: QECKUDVHPFTDIB-UHFFFAOYSA-N
SMILES: CN1CCN(CC2=CC(NC3=NC=CC(NC4=C5C=CC=C(C)C5=NN=C4)=N3)=CC=C2)CC1
Biological Activity: ALK5-IN-27 (Compound EX-04) is a potent ALK-5 inhibitor with an IC50 ≤10 nM. ALK5-IN-27 also inhibits ALK-2 (selectivity ALK2/ALK5 ≤10)[1].
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ALK5-IN-27 | ALK5-IN-27 (Compound EX-04) is a potent ALK-5 inhibitor with an IC50 ≤10 nM. ALK5-IN-27 also inhibits ALK-2 (selectivity ALK2/ALK5 ≤10). | |||||||||||||||||||||
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References
Keywords
