2803879-60-7
2803879-60-7
Chemical Structure
GSPT1 degrader-2
- CAS No.: 2803879-60-7
- Formula:C22H20ClN3O5
- Molecular Weight:441.86
InChIKey: VCEJNBKFGYUOAV-UHFFFAOYSA-N
SMILES: O=C(NC(CC1)=O)C1N2CC(C=CC(COC(NC3=CC(Cl)=C(C)C=C3)=O)=C4)=C4C2=O
Biological Activity: GSPT1 degrader-2 is an orally active GSPT1 molecular glue degrader that promotes the degradation of intracellular GSPT1 protein, with DC50 values of 3 nM and 22 nM in NCI-H1155 and ABC-1 cells with high N-Myc expression, respectively. GSPT1 degrader-2 can be used in the research of N-Myc-driven cancers, such as lung cancer[1].
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GSPT1 degrader-2 | GSPT1 degrader-2 is an orally active GSPT1 molecular glue degrader that promotes the degradation of intracellular GSPT1 protein, with DC50 values of 3 nM and 22 nM in NCI-H1155 and ABC-1 cells with high N-Myc expression, respectively. GSPT1 degrader-2 can be used in the research of N-Myc-driven cancers, such as lung cancer. | |||||||||||||||||||||
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