2863635-04-3
2863635-04-3
Chemical Structure
M4K2163 dihydrochloride
- CAS No.: 2863635-04-3
- Formula:C24H28Cl2FN3O2
- Molecular Weight:480.40
InChIKey: HMNLQIQCOZETBK-UHFFFAOYSA-N
SMILES: FC1=C(C=C(C2=CN=CC(C3=CC=C(N4CCNCC4)C=C3)=C2C)C=C1OC)OC.Cl.Cl
Biological Activity: M4K2163 dihydrochloride is a potent, selective, blood-brain barrier (BBB) permeable activin receptor-like kinase-2 (ALK2) inhibitor, with an IC50 of 19 nM. M4K2163 dihydrochloride can be used in the research of diffuse intrinsic pontine glioma (DIPG)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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M4K2163 dihydrochloride | 98.58% | M4K2163 dihydrochloride is a potent, selective, blood-brain barrier (BBB) permeable activin receptor-like kinase-2 (ALK2) inhibitor, with an IC50 of 19 nM. M4K2163 dihydrochloride can be used in the research of diffuse intrinsic pontine glioma (DIPG). | ||||||||||||||||||||
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References
- [1]. Smil D, et al. Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. J Med Chem. 2020 Sep 10;63(17):10061-10085. [Content Brief]
- [2]. Rooney L, et al. Recent Advances in ALK2 Inhibitors. ACS Omega. 2021 Aug 6;6(32):20729-20734. [Content Brief]
Keywords
