2863678-02-6
Chemical Structure
LJ-2P
- CAS No.: 2863678-02-6
- Formula:C60H52N4O20P2S4
- Molecular Weight:1339.28
InChIKey: CGNKTRZFOLUEHS-UHFFFAOYSA-N
SMILES: OP(OC1=CC2=C(C(C=CC(C3=C(OCCO4)C4=C(C5=C6C(N=S=N6)=C(C7=C8C(OCCO8)=C(C9=CC(C(CCCC(O)=O)(CCCC(O)=O)C%10=C%11C=CC(OP(O)(O)=O)=C%10)=C%11C=C9)S7)C%12=NSN=C5%12)S3)=C%13)=C%13C2(CCCC(O)=O)CCCC(O)=O)C=C1)(O)=O
Biological Activity: LJ-2P is an NIR-II small-molecule fluorescent probe with fibrin/fibrinogen affinity. LJ-2P can bind coagulation-related proteins and restrict dye molecular motion, thereby enhancing local fluorescence for high-contrast imaging of bleeding and blood clots in vivo. LJ-2P can also co-precipitate with Ca2+ to form LJ-2P nanoparticles, significantly enhancing NIR-II luminescence through the precipitation-enhanced emission (PEE) mechanism. LJ-2P can be used for research on bleeding disorders and breast cancer. LJ-2P exhibits dual-modal emission properties (Ex/Em ≈740/945 nm or 740/1066 nm)[1][2].
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LJ-2P | LJ-2P is an NIR-II small-molecule fluorescent probe with fibrin/fibrinogen affinity. LJ-2P can bind coagulation-related proteins and restrict dye molecular motion, thereby enhancing local fluorescence for high-contrast imaging of bleeding and blood clots in vivo. LJ-2P can also co-precipitate with Ca2+ to form LJ-2P nanoparticles, significantly enhancing NIR-II luminescence through the precipitation-enhanced emission (PEE) mechanism. LJ-2P can be used for research on bleeding disorders and breast cancer. LJ-2P exhibits dual-modal emission properties (Ex/Em ≈740/945 nm or 740/1066 nm). | |||||||||||||||||||||
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References
- [1]. Li J, et al. A Small-Molecule NIR-II Probe for the Diagnosis of Hemorrhagic Diseases. Advanced healthcare materials. 2024 Dec;13(31):e2402333.
- [2]. Li J, et al. A Precipitation-Enhanced Emission (PEE) Strategy for Increasing the Brightness and Reducing the Liver Retention of NIR-II Fluorophores. Small. 2022 Dec;18(49):e2204153.
