287183-00-0
Chemical Structure
RWJ-58643
- CAS No.: 287183-00-0
- Formula:C20H26N6O4S
- Molecular Weight:446.52
IUPAC Name: (2S,4R)-1-acetyl-N-(1-(benzo[d]thiazol-2-yl)-5-guanidino-1-oxopentan-2-yl)-4-hydroxypyrrolidine-2-carboxamide
InChIKey: VXDAVYUFYPFGDX-ATFAPYMMSA-N
SMILES: O=C([C@H]1N(C(C)=O)C[C@H](O)C1)NC(C(C2=NC3=CC=CC=C3S2)=O)CCCNC(N)=N
Biological Activity: RWJ-58643 is a β-trypsin inhibitor that suppresses allergic inflammation. RWJ-58643 (100 mg) significantly reduced nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 resulted in late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 modulates allergic responses by inhibiting the release of β-trypsin from mast cells[1].
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RWJ-58643 | RWJ-58643 is a β-trypsin inhibitor that suppresses allergic inflammation. RWJ-58643 (100 mg) significantly reduced nasal allergy symptoms, eosinophil infiltration, and IL-5 levels at low doses. RWJ-58643 resulted in late eosinophilia and elevated IL-5 levels at high doses (300 mg and 600 mg). RWJ-58643 modulates allergic responses by inhibiting the release of β-trypsin from mast cells. | |||||||||||||||||||||
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