2874334-41-3
Chemical Structure
MC-amide-C2-amide-(β-D-GlcUA)-amide-PEG1-CH2-CC-885
- CAS No.: 2874334-41-3
- Formula:C53H61ClN8O18
- Molecular Weight:1133.55
InChIKey: FVGJQHRBLHOBCM-XVPONMENSA-N
SMILES: O=C1N(C2C(NC(CC2)=O)=O)CC3=CC(CNC(NC4=CC(Cl)=C(C=C4)CCOCCN(C)C(OCC5=CC(C(NCCNC(CCCCCN6C(C=CC6=O)=O)=O)=O)=C(C=C5)O[C@@H]7O[C@@H]([C@H]([C@@H]([C@H]7O)O)O)C(O)=O)=O)=O)=CC=C31
Biological Activity: MC-amide-C2-amide-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 is a Drug-Linker Conjugates for ADC composed of CC-885 (HY-101488) and a linker. MC-amide-C2-amide-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 conjugates with GemtUZUmab (HY-P99971) to synthesize an ADC (Compound ADC-2). ADC-2 exhibits anti-tumor activity in a leukemia MV-4-11 xenograft model[1].
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MC-amide-C2-amide-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 | MC-amide-C2-amide-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 is a Drug-Linker Conjugates for ADC composed of CC-885 (HY-101488) and a linker. MC-amide-C2-amide-(β-D-GlcUA)-amide-PEG1-CH2-CC-885 conjugates with GemtUZUmab (HY-P99971) to synthesize an ADC (Compound ADC-2). ADC-2 exhibits anti-tumor activity in a leukemia MV-4-11 xenograft model. | |||||||||||||||||||||
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